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MGP001809

Record overview

MGPD IDMGP001809
Gene ID3945
SpeciesHomo sapiens (Human)
Gene Namelactate dehydrogenase B
Gene Symbol LDHB
SynonymsLDH-B; LDH-H; LDHBD; TRG-5; HEL-S-281;
Alternate namesL-lactate dehydrogenase B chain; LDH heart subunit; epididymis secretory protein Li 281; lactate dehydrogenase H chain; renal carcinoma antigen NY-REN-46;
Chromosome12
Map Location12p12.2-p12.1
EC Number1.1.1.27
SummaryThis gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for LDHB

Proteins

L-lactate dehydrogenase B chain
Refseq ID:NP_001167568
Protein GI:291575128
UniProt ID:P07195
mRNA ID:NM_001174097
Length:334
RefSeq Status:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVR
QQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVA
VWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
 
L-lactate dehydrogenase B chain
Refseq ID:NP_002291
Protein GI:4557032
UniProt ID:P07195
mRNA ID:NM_002300
Length:334
RefSeq Status:
Protein sequence is identical to GI:291575128 (mRNA isoform)
 
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