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MGP001813

Record overview

MGPD IDMGP001813
Gene ID3958
SpeciesHomo sapiens (Human)
Gene Namelectin, galactoside-binding, soluble, 3
Gene Symbol LGALS3
SynonymsL31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2;
Alternate namesgalectin-3; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbohydrate-binding protein 35; galactose-specific lectin 3; laminin-binding protein; lectin L-29;
Chromosome14
Map Location14q22.3
SummaryThis gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]
OrthologsView orthologs and multiple alignments for LGALS3

Proteins

galectin-3 isoform 1
Refseq ID:NP_002297
Protein GI:115430223
UniProt ID:P17931
mRNA ID:NM_002306
Length:250
RefSeq Status:
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGA
YPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKI
QVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI
 
mat_peptide: 2..250
product: galectin-3
experiment: DESCRIPTION:antimicrobial peptide[PMID: 16982911]
calculated_mol_wt: 26021
peptide sequence: 
ADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAY
PATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQ
VLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI
 
galectin-3 isoform 2
Refseq ID:NP_001170859
Protein GI:294345475
UniProt ID:
mRNA ID:NM_001177388
Length:200
RefSeq Status:
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGA
YPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCTYMCKGFMFTVSENFYIHQYPSCKSST
 
mat_peptide: 2..250
product: galectin-3
experiment: DESCRIPTION:antimicrobial peptide[PMID: 16982911]
calculated_mol_wt: 26021
peptide sequence: 
ADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAY
PATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQ
VLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI
 
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