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MGP001814

Record overview

MGPD IDMGP001814
Gene ID3972
SpeciesHomo sapiens (Human)
Gene Nameluteinizing hormone beta polypeptide
Gene Symbol LHB
SynonymsCGB4; hLHB; LSH-B;
Alternate nameslutropin subunit beta; LSH-beta; interstitial cell stimulating hormone, beta chain; luteinizing hormone beta subunit; lutropin beta chain;
Chromosome19
Map Location19q13.32
SummaryThis gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for LHB

Proteins

lutropin subunit beta precursor
Refseq ID:NP_000885
Protein GI:4504989
UniProt ID:P01229
mRNA ID:NM_000894
Length:141
RefSeq Status:
MEMLQGLLLLLLLSMGGAWASREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVV
SFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2161
peptide sequence: 
MEMLQGLLLLLLLSMGGAWA

mat_peptide: 21..141
product: lutropin subunit beta
calculated_mol_wt: 13203
peptide sequence: 
SREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDC
GGPKDHPLTCDHPQLSGLLFL
 
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