MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001819

UniProt Annotations

Entry Information
Gene Nameactin binding LIM protein 1
Protein EntryABLM1_HUMAN
UniProt IDO14639
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; IsoId=O14639-1; Sequence=Displayed; Name=2; IsoId=O14639-2; Sequence=VSP_012100; Name=3; IsoId=O14639-3; Sequence=VSP_012099, VSP_012102; Name=4; IsoId=O14639-4; Sequence=VSP_012099, VSP_012101, VSP_012102; Name=5; IsoId=O14639-5; Sequence=VSP_012099, VSP_041185, VSP_012102; Name=6; IsoId=O14639-6; Sequence=VSP_012100, VSP_041185, VSP_057209; Note=No experimental confirmation available.;
FunctionMay act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}.
InteractionO95751:LDOC1; NbExp=2; IntAct=EBI-487024, EBI-740738;
Sequence CautionSequence=BAA06681.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 1 HP (headpiece) domain. {ECO:0000255|PROSITE-ProRule:PRU00595}.
SimilarityContains 4 LIM zinc-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00125}.
Subcellular LocationCytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with the cytoskeleton. {ECO:0000250}.
SubunitBinds F-actin. Interacts with ABRA. {ECO:0000269|PubMed:17194709}.
Tissue SpecificityDetected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers. {ECO:0000269|PubMed:9245787}.
  logo