MGP Database

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MGP001830

UniProt Annotations

Entry Information
Gene Nameleucyl/cystinyl aminopeptidase
Protein EntryLCAP_HUMAN
UniProt IDQ9UIQ6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9UIQ6-1; Sequence=Displayed; Name=2; IsoId=Q9UIQ6-2; Sequence=VSP_005448; Name=3; IsoId=Q9UIQ6-3; Sequence=VSP_005449;
Catalytic ActivityRelease of an N-terminal amino acid, Cys-|- Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:1731608}.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionRelease of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.
PtmN-glycosylated. {ECO:0000269|PubMed:19349973}.
PtmThe pregnancy serum form is derived from the membrane-bound form by proteolytic processing.
Sequence CautionSequence=BAA09436.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92120.1; Type=Frameshift; Positions=405; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase M1 family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:11389728}; Single-pass type II membrane protein {ECO:0000269|PubMed:11389728}. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.
Subcellular LocationLeucyl-cystinyl aminopeptidase, pregnancy serum form: Secreted. Note=During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.
SubunitHomodimer. Binds tankyrases 1 and 2.
Tissue SpecificityHighly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:8550619, ECO:0000269|PubMed:9177475}.
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