MGP Database

MGP001846

Record overview

MGPD ID	MGP001846
Gene ID	4057
Species	Homo sapiens (Human)
Gene Name	lactotransferrin
Gene Symbol	LTF
Synonyms	LF; HLF2; GIG12; HEL110;
Alternate names	lactotransferrin; epididymis luminal protein 110; growth-inhibiting protein 12; kaliocin-1; lactoferricin; lactoferroxin; neutrophil lactoferrin; talalactoferrin;
Chromosome	3
Map Location	3p21.31
EC Number	3.4.21.-
Summary	This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Orthologs	View orthologs and multiple alignments for LTF

Proteins

lactotransferrin isoform 1 precursor

Refseq ID:	NP_002334
Protein GI:	54607120
UniProt ID:	P02788
mRNA ID:	NM_002343
Length:	710
RefSeq Status:

MKLVFLVLLFLGALGLCLAGRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEV
YGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKC
AFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKD
KSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCI
ALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTG
SCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRK
PVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSP
LLEACEFLRK

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2035
peptide sequence: 
MKLVFLVLLFLGALGLCLA

mat_peptide: 20..710
product: Lactotransferrin
experiment: DESCRIPTION:antimicrobial peptide[PMID: 16261253]
calculated_mol_wt: 76166
peptide sequence: 
GRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKK
GGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLR
DGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLF
KDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVY
TAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPR
SNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVV
SRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK

mat_peptide: 20..67
product: Lactoferricin-H
experiment: DESCRIPTION:antimicrobial peptide[PMID: 16261253]
calculated_mol_wt: 5588
peptide sequence: 
GRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQA

mat_peptide: 171..201
product: Kaliocin-1
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12693969]
calculated_mol_wt: 3193
peptide sequence: 
FFSASCVPGADKGQFPNLCRLCAGTGENKCA

mat_peptide: 338..343
product: Lactoferroxin-A
experiment: experimental evidence, no additional details recorded
calculated_mol_wt: 659
peptide sequence: 
YLGSGY

mat_peptide: 543..547
product: Lactoferroxin-B
experiment: experimental evidence, no additional details recorded
calculated_mol_wt: 721
peptide sequence: 
RYYGY

mat_peptide: 680..686
product: Lactoferroxin-C
experiment: experimental evidence, no additional details recorded
calculated_mol_wt: 868
peptide sequence: 
KYLGPQY

lactotransferrin isoform 2

Refseq ID:	NP_001186078
Protein GI:	312433998
UniProt ID:	P02788
mRNA ID:	NM_001199149
Length:	666
RefSeq Status:

MRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGW
NVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERD
EYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYF
TAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDP
NCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERY
YGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGS
DCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2035
peptide sequence: 
MKLVFLVLLFLGALGLCLA

mat_peptide: 20..710
product: Lactotransferrin
experiment: DESCRIPTION:antimicrobial peptide[PMID: 16261253]
calculated_mol_wt: 76166
peptide sequence: 
GRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKK
GGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLR
DGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLF
KDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVY
TAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPR
SNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVV
SRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK

mat_peptide: 20..67
product: Lactoferricin-H
experiment: DESCRIPTION:antimicrobial peptide[PMID: 16261253]
calculated_mol_wt: 5588
peptide sequence: 
GRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQA

mat_peptide: 171..201
product: Kaliocin-1
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12693969]
calculated_mol_wt: 3193
peptide sequence: 
FFSASCVPGADKGQFPNLCRLCAGTGENKCA

mat_peptide: 338..343
product: Lactoferroxin-A
experiment: experimental evidence, no additional details recorded
calculated_mol_wt: 659
peptide sequence: 
YLGSGY

mat_peptide: 543..547
product: Lactoferroxin-B
experiment: experimental evidence, no additional details recorded
calculated_mol_wt: 721
peptide sequence: 
RYYGY

mat_peptide: 680..686
product: Lactoferroxin-C
experiment: experimental evidence, no additional details recorded
calculated_mol_wt: 868
peptide sequence: 
KYLGPQY