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MGP001847

UniProt Annotations

Entry Information
Gene Namelumican
Protein EntryLUM_HUMAN
UniProt IDP51884
SpeciesHuman
Comments
Comment typeDescription
Developmental StagePresent in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.
InteractionP50281:MMP14; NbExp=2; IntAct=EBI-725780, EBI-992788;
PtmSulfated on tyrosine residue(s). {ECO:0000269|PubMed:14551184}.
SimilarityBelongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. {ECO:0000305}.
SimilarityContains 11 LRR (leucine-rich) repeats. {ECO:0000305}.
SimilarityContains 1 LRRNT domain. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space, extracellular matrix {ECO:0000250}.
SubunitBinds to laminin. {ECO:0000250}.
Tissue SpecificityCornea and other tissues.
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