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MGP001859

Record overview

MGPD IDMGP001859
Gene ID4092
SpeciesHomo sapiens (Human)
Gene NameSMAD family member 7
Gene Symbol SMAD7
SynonymsCRCS3; MADH7; MADH8;
Alternate namesmothers against decapentaplegic homolog 7; MAD (mothers against decapentaplegic, Drosophila) homolog 7; MAD homolog 8; Mothers against decapentaplegic, drosophila, homolog of, 7; SMAD, mothers against DPP homolog 7; hSMAD7; mothers against DPP homolog 8;
Chromosome18
Map Location18q21.1
SummaryThe protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
OrthologsView orthologs and multiple alignments for SMAD7

Proteins

mothers against decapentaplegic homolog 7 isoform 1
Refseq ID:NP_005895
Protein GI:5174517
UniProt ID:O15105
mRNA ID:NM_005904
Length:426
RefSeq Status:
MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHHHPHPPAAGAGAAGGAEADLKALTHSVL
KKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSR
LCELESPPPPYSRYPMDFLKPTADCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQ
LNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFV
KGWGQCYTRQFISSCPCWLEVIFNSR
 
mothers against decapentaplegic homolog 7 isoform 2
Refseq ID:NP_001177750
Protein GI:299890805
UniProt ID:O15105
mRNA ID:NM_001190821
Length:425
RefSeq Status:
MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHHHPHPPAAGAGAAGGAEADLKALTHSVL
KKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSR
LCELESPPPPYSRYPMDFLKPTDCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQL
NSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVK
GWGQCYTRQFISSCPCWLEVIFNSR
 
mothers against decapentaplegic homolog 7 isoform 3
Refseq ID:NP_001177751
Protein GI:299890807
UniProt ID:O15105
mRNA ID:NM_001190822
Length:211
RefSeq Status:
MDFLKPTADCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRS
KIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSC
PCWLEVIFNSR
 
mothers against decapentaplegic homolog 7 isoform 4
Refseq ID:NP_001177752
Protein GI:299890811
UniProt ID:O15105
mRNA ID:NM_001190823
Length:238
RefSeq Status:
MCGLSFMLFRACLKMDLGVFICVFISFSPLFKSTADCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFY
DLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQ
PWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR
 
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