MGP Database

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MGP001866

UniProt Annotations

Entry Information
Gene Namemannosidase, alpha, class 2A, member 1
Protein EntryMA2A1_HUMAN
UniProt IDQ16706
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityHydrolysis of the terminal (1->3)- and (1->6)- linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionCatalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyl hydrolase 38 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
SubunitHomodimer; disulfide-linked. {ECO:0000250}.
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