MGP Database

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MGP001867

Ontology/Pathway Information

Entrez Gene ID4128
Gene Namemonoamine oxidase A
Gene Symbol MAOA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0005741 TAS:ParkinsonsUK-UCLCmitochondrial outer membrane
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0008131 TAS:ReactomeFprimary amine oxidase activity
GO:0006576 TAS:ProtIncPcellular biogenic amine metabolic process
GO:0042420 TAS:ParkinsonsUK-UCLPdopamine catabolic process
GO:0042136 TAS:ReactomePneurotransmitter biosynthetic process
GO:0042135 IEA:UniProtKB-KWPneurotransmitter catabolic process
GO:0007269 TAS:ReactomePneurotransmitter secretion
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1875Amine Oxidase reactions
REACT_416Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
REACT_13433Biological oxidations
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_15514Dopamine clearance from the synaptic cleft
REACT_15548Enzymatic degradation of dopamine by COMT
REACT_15511Enzymatic degradation of Dopamine by monoamine oxidase
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_15532Metabolism of serotonin
REACT_13685Neuronal System
REACT_13583Neurotransmitter Clearance In The Synaptic Cleft
REACT_13723Neurotransmitter Release Cycle
REACT_15418Norepinephrine Neurotransmitter Release Cycle
REACT_13705Phase 1 - Functionalization of compounds
REACT_15391Serotonin clearance from the synaptic cleft
REACT_13477Transmission across Chemical Synapses
SMP Pathway Links
SMP IDDescription
SMP007213-Phosphoglycerate dehydrogenase deficiency
SMP00169Alkaptonuria
SMP00424Citalopram Action Pathway
SMP00627Citalopram Metabolism Pathway
SMP00179Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
SMP00242Dimethylglycine Dehydrogenase Deficiency
SMP00484Dimethylglycinuria
SMP00429Disulfiram Action Pathway
SMP00498Dopamine beta-hydroxylase deficiency
SMP00004Glycine and Serine Metabolism
SMP00190Hawkinsinuria
SMP00044Histidine Metabolism
SMP00191Histidinemia
SMP00485Hyperglycinemia, non-ketotic
SMP00533Monoamine oxidase-a deficiency (MAO-A)
SMP00223Non Ketotic Hyperglycinemia
SMP00244Sarcosinemia
SMP00006Tyrosine Metabolism
SMP00494Tyrosinemia, transient, of the newborn
SMP00218Tyrosinemia Type I
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