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MGP001868

UniProt Annotations

Entry Information
Gene Namemonoamine oxidase B
Protein EntryAOFB_HUMAN
UniProt IDP27338
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27338-1; Sequence=Displayed; Name=2; IsoId=P27338-2; Sequence=VSP_057047, VSP_057048, VSP_057049; Note=No experimental confirmation available.;
Catalytic ActivityRCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
FunctionCatalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
Mass SpectrometryMass=59474; Mass_error=14.0; Method=Electrospray; Range=2-520; Evidence={ECO:0000269|PubMed:11049757};
SimilarityBelongs to the flavin monoamine oxidase family. {ECO:0000305}.
Subcellular LocationMitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
SubunitMonomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity). {ECO:0000250}.
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=MAOB";
Web ResourceName=Wikipedia; Note=Monoamine oxidase entry; URL="http://en.wikipedia.org/wiki/Monoamine_oxidase";
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