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MGP001871

Record overview

MGPD IDMGP001871
Gene ID4143
SpeciesHomo sapiens (Human)
Gene Namemethionine adenosyltransferase I, alpha
Gene Symbol MAT1A
SynonymsMAT; SAMS; MATA1; SAMS1;
Alternate namesS-adenosylmethionine synthase isoform type-1; MAT 1; MAT-I/III; S-adenosylmethionine synthetase isoform type-1; adoMet synthase 1; adoMet synthetase 1; methionine adenosyltransferase 1; methionine adenosyltransferase I/III;
Chromosome10
Map Location10q22
EC Number2.5.1.6
SummaryThis gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MAT1A

Proteins

S-adenosylmethionine synthase isoform type-1
Refseq ID:NP_000420
Protein GI:4557737
UniProt ID:Q00266
mRNA ID:NM_000429
Length:395
RefSeq Status:
MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFD
FKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRI
HTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF
 
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