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MGP001872

UniProt Annotations

Entry Information
Gene Namemethionine adenosyltransferase II, alpha
Protein EntryMETK2_HUMAN
UniProt IDP31153
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31153-1; Sequence=Displayed; Name=2; IsoId=P31153-2; Sequence=VSP_056186, VSP_056187; Note=No experimental confirmation available.;
Catalytic ActivityATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.
CofactorName=K(+); Xref=ChEBI:CHEBI:29103; Evidence={ECO:0000250}; Note=Binds 1 potassium ion per subunit. {ECO:0000250};
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250}; Note=Binds 2 divalent ions per subunit. Magnesium or cobalt. {ECO:0000250};
FunctionCatalyzes the formation of S-adenosylmethionine from methionine and ATP.
PathwayAmino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
PtmThe alpha' subunit is a post-translationally modified version of MAT2A.
SimilarityBelongs to the AdoMet synthase family. {ECO:0000305}.
SubunitHeterotetramer composed of 2 catalytic alpha subunits (alpha and alpha') (MAT2A) and 1 copy of beta subunit (MAT2B). {ECO:0000269|PubMed:10644686}.
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