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MGP001886

UniProt Annotations

Entry Information
Gene Nameminichromosome maintenance complex component 3
Protein EntryMCM3_HUMAN
UniProt IDP25205
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P25205-1; Sequence=Displayed; Name=2; IsoId=P25205-2; Sequence=VSP_057050; Note=No experimental confirmation available.;
Catalytic ActivityATP + H(2)O = ADP + phosphate.
FunctionActs as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
InteractionP62805:HIST2H4B; NbExp=2; IntAct=EBI-355153, EBI-302023; P49736:MCM2; NbExp=5; IntAct=EBI-355153, EBI-374819; P33992:MCM5; NbExp=4; IntAct=EBI-355153, EBI-359410; Q14566:MCM6; NbExp=2; IntAct=EBI-355153, EBI-374900; Q9BTE3:MCMBP; NbExp=11; IntAct=EBI-355153, EBI-749378; Q13416:ORC2; NbExp=2; IntAct=EBI-355153, EBI-374957;
MiscellaneousEarly fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.
PtmO-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000269|PubMed:22967762}.
SimilarityBelongs to the MCM family. {ECO:0000305}.
SimilarityContains 1 MCM domain. {ECO:0000305}.
Subcellular LocationNucleus.
SubunitComponent of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6- MCM4-MCM7-MCM3-MCM5 (By simililarity). Associated with the replication-specific DNA polymerase alpha. Interacts with MCMBP. Interacts with ANKRD17. {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:17296731, ECO:0000269|PubMed:23711367}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mcm3/";
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