MGP Database

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MGP001888

Record overview

MGPD IDMGP001888
Gene ID4174
SpeciesHomo sapiens (Human)
Gene Nameminichromosome maintenance complex component 5
Gene Symbol MCM5
SynonymsCDC46; P1-CDC46;
Alternate namesDNA replication licensing factor MCM5; CDC46 homolog; MCM5 minichromosome maintenance deficient 5, cell division cycle 46; minichromosome maintenance deficient 5 (cell division cycle 46);
Chromosome22
Map Location22q13.1
EC Number3.6.4.12
SummaryThe protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MCM5

Proteins

DNA replication licensing factor MCM5
Refseq ID:NP_006730
Protein GI:23510448
UniProt ID:P33992
mRNA ID:NM_006739
Length:734
RefSeq Status:
MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLE
EAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTD
QAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQ
VDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPI
GVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG
EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDS
DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGVEGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTK
QKYPEHAIHKVLQLMLRRGEIQHRMQRKVLYRLK
 
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