MGP Database

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MGP001900

Ontology/Pathway Information

Entrez Gene ID4208
Gene Namemyocyte enhancer factor 2C
Gene Symbol MEF2C
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 ISS:Alzheimers_University_of_TorontoCcytosol
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0016607 IDA:BHF-UCLCnuclear speck
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0043234 IDA:UniProtKBCprotein complex
GO:0033613 IPI:UniProtKBFactivating transcription factor binding
GO:0003680 IDA:UniProtKBFAT DNA binding
GO:0003682 IEA:EnsemblFchromatin binding
GO:0001046 IEA:EnsemblFcore promoter sequence-specific DNA binding
GO:0003677 IDA:UniProtKBFDNA binding
GO:0035198 IDA:UniProtKBFmiRNA binding
GO:0046982 IPI:UniProtKBFprotein heterodimerization activity
GO:0000978 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:UniProtKBFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000983 IDA:UniProtKBFRNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000980 IEA:EnsemblFRNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205 IEA:EnsemblFRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000977 IDA:UniProtKBFRNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 ISS:UniProtKBFsequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 IDA:BHF-UCLFsequence-specific DNA binding transcription factor activity
GO:0044212 ISS:BHF-UCLFtranscription regulatory region DNA binding
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0001782 ISS:UniProtKBPB cell homeostasis
GO:0042100 ISS:UniProtKBPB cell proliferation
GO:0050853 ISS:UniProtKBPB cell receptor signaling pathway
GO:0001568 ISS:UniProtKBPblood vessel development
GO:0001974 ISS:UniProtKBPblood vessel remodeling
GO:0014898 IEA:EnsemblPcardiac muscle hypertrophy in response to stress
GO:0003211 ISS:UniProtKBPcardiac ventricle formation
GO:0060536 IEA:EnsemblPcartilage morphogenesis
GO:0048667 ISS:Alzheimers_University_of_TorontoPcell morphogenesis involved in neuron differentiation
GO:0071277 ISS:UniProtKBPcellular response to calcium ion
GO:0035690 ISS:UniProtKBPcellular response to drug
GO:0071498 ISS:UniProtKBPcellular response to fluid shear stress
GO:0071222 ISS:UniProtKBPcellular response to lipopolysaccharide
GO:0071374 IDA:UniProtKBPcellular response to parathyroid hormone stimulus
GO:0071560 IDA:UniProtKBPcellular response to transforming growth factor beta stimulus
GO:0035984 ISS:UniProtKBPcellular response to trichostatin A
GO:0002062 ISS:UniProtKBPchondrocyte differentiation
GO:0048703 IEA:EnsemblPembryonic viscerocranium morphogenesis
GO:0001958 ISS:UniProtKBPendochondral ossification
GO:2001013 ISS:UniProtKBPepithelial cell proliferation involved in renal tubule morphogenesis
GO:0002467 ISS:UniProtKBPgerminal center formation
GO:0072102 ISS:UniProtKBPglomerulus morphogenesis
GO:0007507 IEP:UniProtKBPheart development
GO:0001947 ISS:UniProtKBPheart looping
GO:0006959 ISS:UniProtKBPhumoral immune response
GO:0045087 TAS:ReactomePinnate immune response
GO:0007611 ISS:UniProtKBPlearning or memory
GO:0000165 IDA:UniProtKBPMAPK cascade
GO:0030318 ISS:UniProtKBPmelanocyte differentiation
GO:0030224 IEA:EnsemblPmonocyte differentiation
GO:0042692 TAS:ReactomePmuscle cell differentiation
GO:0007521 ISS:UniProtKBPmuscle cell fate determination
GO:0007517 TAS:ProtIncPmuscle organ development
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0014902 IEP:UniProtKBPmyotube differentiation
GO:0050680 IEA:EnsemblPnegative regulation of epithelial cell proliferation
GO:0010629 ISS:UniProtKBPnegative regulation of gene expression
GO:0043524 ISS:UniProtKBPnegative regulation of neuron apoptotic process
GO:0030279 IDA:UniProtKBPnegative regulation of ossification
GO:0000122 IMP:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0072160 ISS:UniProtKBPnephron tubule epithelial cell differentiation
GO:0007399 TAS:ProtIncPnervous system development
GO:0014033 ISS:UniProtKBPneural crest cell differentiation
GO:0048666 ISS:UniProtKBPneuron development
GO:0030182 IEP:UniProtKBPneuron differentiation
GO:0001764 ISS:Alzheimers_University_of_TorontoPneuron migration
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0001649 ISS:UniProtKBPosteoblast differentiation
GO:0003151 ISS:UniProtKBPoutflow tract morphogenesis
GO:0060021 IEA:EnsemblPpalate development
GO:0030220 ISS:UniProtKBPplatelet formation
GO:0010694 ISS:UniProtKBPpositive regulation of alkaline phosphatase activity
GO:0030890 ISS:UniProtKBPpositive regulation of B cell proliferation
GO:2000987 ISS:UniProtKBPpositive regulation of behavioral fear response
GO:0030501 ISS:UniProtKBPpositive regulation of bone mineralization
GO:2000727 IDA:UniProtKBPpositive regulation of cardiac muscle cell differentiation
GO:0060045 ISS:UniProtKBPpositive regulation of cardiac muscle cell proliferation
GO:0071864 IEA:EnsemblPpositive regulation of cell proliferation in bone marrow
GO:0010628 IDA:UniProtKBPpositive regulation of gene expression
GO:2000111 ISS:UniProtKBPpositive regulation of macrophage apoptotic process
GO:0043406 ISS:Alzheimers_University_of_TorontoPpositive regulation of MAP kinase activity
GO:0051149 TAS:ReactomePpositive regulation of muscle cell differentiation
GO:0045663 IMP:UniProtKBPpositive regulation of myoblast differentiation
GO:0045666 ISS:UniProtKBPpositive regulation of neuron differentiation
GO:0045669 ISS:UniProtKBPpositive regulation of osteoblast differentiation
GO:0090073 ISS:UniProtKBPpositive regulation of protein homodimerization activity
GO:2001016 IDA:UniProtKBPpositive regulation of skeletal muscle cell differentiation
GO:0048643 IMP:UniProtKBPpositive regulation of skeletal muscle tissue development
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0003138 ISS:UniProtKBPprimary heart field specification
GO:2000311 ISS:Alzheimers_University_of_TorontoPregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0060998 ISS:Alzheimers_University_of_TorontoPregulation of dendritic spine development
GO:0060079 ISS:Alzheimers_University_of_TorontoPregulation of excitatory postsynaptic membrane potential
GO:0002634 ISS:UniProtKBPregulation of germinal center formation
GO:0045652 ISS:UniProtKBPregulation of megakaryocyte differentiation
GO:0043523 ISS:Alzheimers_University_of_TorontoPregulation of neuron apoptotic process
GO:0046928 ISS:Alzheimers_University_of_TorontoPregulation of neurotransmitter secretion
GO:2000310 ISS:Alzheimers_University_of_TorontoPregulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:0060297 IEA:EnsemblPregulation of sarcomere organization
GO:0051963 ISS:Alzheimers_University_of_TorontoPregulation of synapse assembly
GO:0060025 ISS:UniProtKBPregulation of synaptic activity
GO:0048167 ISS:Alzheimers_University_of_TorontoPregulation of synaptic plasticity
GO:0051966 ISS:Alzheimers_University_of_TorontoPregulation of synaptic transmission, glutamatergic
GO:0006355 IDA:Alzheimers_University_of_TorontoPregulation of transcription, DNA-templated
GO:0061333 ISS:UniProtKBPrenal tubule morphogenesis
GO:0002931 ISS:Alzheimers_University_of_TorontoPresponse to ischemia
GO:0009615 IEP:UniProtKBPresponse to virus
GO:0003139 ISS:UniProtKBPsecondary heart field specification
GO:0003185 ISS:UniProtKBPsinoatrial valve morphogenesis
GO:0007519 ISS:UniProtKBPskeletal muscle tissue development
GO:0051145 ISS:UniProtKBPsmooth muscle cell differentiation
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0006366 IDA:GOCPtranscription from RNA polymerase II promoter
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
GO:0055012 ISS:UniProtKBPventricular cardiac muscle cell differentiation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_21402CDO in myogenesis
REACT_24941Circadian Clock
REACT_111045Developmental Biology
REACT_12599ERK/MAPK targets
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_264351Mitochondrial biogenesis
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_21303Myogenesis
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12433Nuclear Events (kinase and transcription factor activation)
REACT_264135Organelle biogenesis and maintenance
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_264212Transcriptional activation of mitochondrial biogenesis
REACT_25281TRIF-mediated TLR3/TLR4 signaling
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