MGP Database

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MGP001906

Ontology/Pathway Information

Entrez Gene ID4217
Gene Namemitogen-activated protein kinase kinase kinase 5
Gene Symbol MAP3K5
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005783 IEA:UniProtKB-SubCellCendoplasmic reticulum
GO:1902911 IDA:ParkinsonsUK-UCLCprotein kinase complex
GO:0005524 IDA:UniProtKBFATP binding
GO:0008656 IDA:UniProtKBFcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0004709 IDA:UniProtKBFMAP kinase kinase kinase activity
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0004672 IDA:UniProtKBFprotein kinase activity
GO:0019903 IPI:BHF-UCLFprotein phosphatase binding
GO:0006919 IDA:GOCPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007257 TAS:ProtIncPactivation of JUN kinase activity
GO:0000186 IDA:BHF-UCLPactivation of MAPKK activity
GO:0097190 TAS:ProtIncPapoptotic signaling pathway
GO:0070301 IDA:BHF-UCLPcellular response to hydrogen peroxide
GO:1902170 IEA:EnsemblPcellular response to reactive nitrogen species
GO:0045087 IEA:UniProtKB-KWPinnate immune response
GO:0008631 IDA:UniProtKBPintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254 IDA:UniProtKBPJNK cascade
GO:0000165 IDA:UniProtKBPMAPK cascade
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0043280 IDA:BHF-UCLPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1901216 IGI:ParkinsonsUK-UCLPpositive regulation of neuron death
GO:0097300 IEA:EnsemblPprogrammed necrotic cell death
GO:0006468 IDA:ParkinsonsUK-UCLPprotein phosphorylation
GO:0002931 IEA:EnsemblPresponse to ischemia
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_169436Oxidative Stress Induced Senescence
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