MGP Database

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MGP001931

Ontology/Pathway Information

Entrez Gene ID4297
Gene Namelysine (K)-specific methyltransferase 2A
Gene Symbol KMT2A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0035097 IDA:UniProtKBChistone methyltransferase complex
GO:0071339 IDA:UniProtKBCMLL1 complex
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0003680 NAS:UniProtKBFAT DNA binding
GO:0003682 IEA:EnsemblFchromatin binding
GO:0001046 ISS:UniProtKBFcore promoter sequence-specific DNA binding
GO:0042800 IDA:UniProtKBFhistone methyltransferase activity (H3-K4 specific)
GO:0042802 IPI:IntActFidentical protein binding
GO:0070577 IDA:UniProtKBFlysine-acetylated histone binding
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0003700 NAS:ProtIncFsequence-specific DNA binding transcription factor activity
GO:0044212 IDA:UniProtKBFtranscription regulatory region DNA binding
GO:0045322 IDA:UniProtKBFunmethylated CpG binding
GO:0008270 IDA:UniProtKBFzinc ion binding
GO:0009952 IEA:EnsemblPanterior/posterior pattern specification
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0032922 ISS:UniProtKBPcircadian regulation of gene expression
GO:0006306 IEA:EnsemblPDNA methylation
GO:0035162 TAS:UniProtKBPembryonic hemopoiesis
GO:0051568 IDA:UniProtKBPhistone H3-K4 methylation
GO:0080182 IDA:BHF-UCLPhistone H3-K4 trimethylation
GO:0043984 IMP:UniProtKBPhistone H4-K16 acetylation
GO:0008285 IEA:EnsemblPnegative regulation of cell proliferation
GO:2001040 IMP:BHF-UCLPpositive regulation of cellular response to drug
GO:0051571 ISS:UniProtKBPpositive regulation of histone H3-K4 methylation
GO:0045893 IMP:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0032411 IMP:BHF-UCLPpositive regulation of transporter activity
GO:0006461 IDA:UniProtKBPprotein complex assembly
GO:0071440 ISS:UniProtKBPregulation of histone H3-K14 acetylation
GO:2000615 ISS:UniProtKBPregulation of histone H3-K9 acetylation
GO:0006366 TAS:ProtIncPtranscription from RNA polymerase II promoter
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264165Chromatin modifying enzymes
REACT_264155Chromatin organization
REACT_268728PKMTs methylate histone lysines
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