MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001941

UniProt Annotations

Entry Information
Gene Namematrix metallopeptidase 10 (stromelysin 2)
Protein EntryMMP10_HUMAN
UniProt IDP09238
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivitySimilar to stromelysin 1, but action on collagen types III, IV and V is weak. {ECO:0000269|PubMed:15095982}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:15095982};
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:15095982}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000269|PubMed:15095982};
DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
FunctionCan degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
SimilarityBelongs to the peptidase M10A family. {ECO:0000305}.
SimilarityContains 4 hemopexin repeats. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space, extracellular matrix {ECO:0000305}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mmp10/";
  logo