MGP Database

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MGP001942

UniProt Annotations

Entry Information
Gene Namematrix metallopeptidase 11 (stromelysin 3)
Protein EntryMMP11_HUMAN
UniProt IDP24347
SpeciesHuman
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
FunctionMay play an important role in the progression of epithelial malignancies.
PtmThe precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
SimilarityBelongs to the peptidase M10A family. {ECO:0000305}.
SimilarityContains 4 hemopexin repeats. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space, extracellular matrix {ECO:0000305}.
Tissue SpecificitySpecifically expressed in stromal cells of breast carcinomas.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ST3ID200.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mmp11/";
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