MGP Database

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MGP001953

Record overview

MGPD IDMGP001953
Gene ID4345
SpeciesHomo sapiens (Human)
Gene NameCD200 molecule
Gene Symbol CD200
SynonymsMRC; MOX1; MOX2; OX-2;
Alternate namesOX-2 membrane glycoprotein; CD200 antigen; MRC OX-2 antigen; antigen identified by monoclonal antibody MRC OX-2;
Chromosome3
Map Location3q13.2
SummaryThe protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CD200

Proteins

OX-2 membrane glycoprotein isoform a precursor
Refseq ID:NP_005935
Protein GI:90903247
UniProt ID:P41217
mRNA ID:NM_005944
Length:269
RefSeq Status:
MERLVIRMPFSHLSTYSLVWVMAAVVLCTAQVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLG
LQNSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILH
IKDPKNQVGKEVICQVLHLGTVTDFKQTVNKGYWFSVPLLLSIVSLVILLVLISILLYWKRHRNQDREP
 
sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3425
peptide sequence: 
MERLVIRMPFSHLSTYSLVWVMAAVVLCTA
 
OX-2 membrane glycoprotein isoform b
Refseq ID:NP_001004196
Protein GI:90903245
UniProt ID:P41217
mRNA ID:NM_001004196
Length:294
RefSeq Status:
MERLTLTRTIGGPLLTATLLGKTTINDYQVIRMPFSHLSTYSLVWVMAAVVLCTAQVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENM
VTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVP
RSGIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVNKGYWFSVPLLLSIVSLVILLVLISILLYWKRHRNQDREP
 
sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3425
peptide sequence: 
MERLVIRMPFSHLSTYSLVWVMAAVVLCTA
 
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