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MGP001958

Record overview

MGPD IDMGP001958
Gene ID4357
SpeciesHomo sapiens (Human)
Gene Namemercaptopyruvate sulfurtransferase
Gene Symbol MPST
SynonymsMST; TST2; TUM1;
Alternate names3-mercaptopyruvate sulfurtransferase; human liver rhodanese; tRNA thiouridin modification protein 1;
Chromosome22
Map Location22q13.1
EC Number2.8.1.2;
SummaryThis protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MPST

Proteins

3-mercaptopyruvate sulfurtransferase isoform 1
Refseq ID:NP_066949
Protein GI:194473668
UniProt ID:P25325
mRNA ID:NM_021126
Length:317
RefSeq Status:
MAEPGSRESETRARSPSVAAMASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFFDIDQCSDRTSPYDHMLPGAE
HFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAFGHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV
VDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDLSKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWY
MRARPEDVISEGRGKTH
 
3-mercaptopyruvate sulfurtransferase isoform 2
Refseq ID:NP_001123989
Protein GI:194473681
UniProt ID:P25325
mRNA ID:NM_001130517
Length:297
RefSeq Status:
MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFFDIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIY
DASDQGLYSAPRVWWMFRAFGHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQVVDSRATGRFRGTEPEPRDGI
EPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDLSKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWYMRARPEDVISEGRGKTH
 
3-mercaptopyruvate sulfurtransferase isoform 2
Refseq ID:NP_001013454
Protein GI:61835204
UniProt ID:P25325
mRNA ID:NM_001013436
Length:297
RefSeq Status:
Protein sequence is identical to GI:194473681 (mRNA isoform)
 
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