MGP Database

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MGP001959

UniProt Annotations

Entry Information
Gene Namemannose receptor, C type 1
Protein EntryMRC1_HUMAN
UniProt IDP22897
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P22897-1; Sequence=Displayed; Name=2; IsoId=P22897-2; Sequence=VSP_041340, VSP_041341; Note=No experimental confirmation available.;
FunctionMediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
MiscellaneousCRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.
PolymorphismGenetic variations in MRC1 may influence susceptibility or resistance to leprosy in some populations. Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407.
Sequence CautionSequence=CAH70733.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH70872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71176.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityContains 1 fibronectin type-II domain. {ECO:0000255|PROSITE-ProRule:PRU00479}.
SimilarityContains 1 ricin B-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00174}.
SimilarityContains 8 C-type lectin domains. {ECO:0000255|PROSITE-ProRule:PRU00040}.
Subcellular LocationEndosome membrane {ECO:0000269|PubMed:20035344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20035344}. Cell membrane {ECO:0000269|PubMed:20035344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20035344}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MRC1ID44561ch10p12.html";
Web ResourceName=Functional Glycomics Gateway - Glycan Binding; Note=Macrophage mannose receptor; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00127";
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