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MGP001968

UniProt Annotations

Entry Information
Gene Namemetallothionein 2A
Protein EntryMT2_HUMAN
UniProt IDP02795
SpeciesHuman
Comments
Comment typeDescription
DomainClass I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
FunctionMetallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
InteractionQ8TE69:CXorf40A; NbExp=2; IntAct=EBI-996616, EBI-996609; Q13585:GPR50; NbExp=2; IntAct=EBI-996616, EBI-8550965; Q15139:PRKD1; NbExp=7; IntAct=EBI-996616, EBI-1181072; P58062:SPINK7; NbExp=7; IntAct=EBI-996616, EBI-1182445;
MiscellaneousThis metallothionein binds zinc.
SimilarityBelongs to the metallothionein superfamily. Type 1 family. {ECO:0000305}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mt2a/";
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