MGP Database

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MGP001989

Ontology/Pathway Information

Entrez Gene ID4598
Gene Namemevalonate kinase
Gene Symbol MVK
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IDA:UniProtKBCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0004496 IDA:UniProtKBFmevalonate kinase activity
GO:0006695 IDA:UniProtKBPcholesterol biosynthetic process
GO:0019287 IEA:UniProtKB-UniPathwayPisopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0008299 IDA:UniProtKBPisoprenoid biosynthetic process
GO:0050728 IMP:BHF-UCLPnegative regulation of inflammatory response
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147904Activation of gene expression by SREBF (SREBP)
REACT_9405Cholesterol biosynthesis
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_147797Regulation of cholesterol biosynthesis by SREBP (SREBF)
SMP Pathway Links
SMP IDDescription
SMP00095Alendronate Action Pathway
SMP00131Atorvastatin Action Pathway
SMP00111Cerivastatin Action Pathway
SMP00387CHILD Syndrome
SMP00508Cholesteryl ester storage disease
SMP00388Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)
SMP00386Desmosterolosis
SMP00119Fluvastatin Action Pathway
SMP00209Hypercholesterolemia
SMP00509Hyper-IgD syndrome
SMP00079Ibandronate Action Pathway
SMP00099Lovastatin Action Pathway
SMP00319Lysosomal Acid Lipase Deficiency (Wolman Disease)
SMP00510Mevalonic aciduria
SMP00117Pamidronate Action Pathway
SMP00089Pravastatin Action Pathway
SMP00112Risedronate Action Pathway
SMP00092Rosuvastatin Action Pathway
SMP00082Simvastatin Action Pathway
SMP00389Smith-Lemli-Opitz Syndrome (SLOS)
SMP00023Steroid Biosynthesis
SMP00511Wolman disease
SMP00107Zoledronate Action Pathway
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