MGP Database

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MGP001991

UniProt Annotations

Entry Information
Gene NameMX dynamin-like GTPase 2
Protein EntryMX2_HUMAN
UniProt IDP20592
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P20592-1; Sequence=Displayed; Name=2; IsoId=P20592-2; Sequence=VSP_056443, VSP_056444, VSP_056445; Note=No experimental confirmation available.;
FunctionInterferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. {ECO:0000269|PubMed:15184662, ECO:0000269|PubMed:24048477, ECO:0000269|PubMed:24055605, ECO:0000269|PubMed:24121441}.
InductionBy type I and type III interferons. {ECO:0000269|PubMed:18062906}.
SimilarityBelongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. {ECO:0000305}.
SimilarityContains 1 dynamin-type G (guanine nucleotide-binding) domain. {ECO:0000305}.
SimilarityContains 1 GED domain. {ECO:0000255|PROSITE- ProRule:PRU00720}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:15184662}. Nucleus {ECO:0000269|PubMed:15184662}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15184662}. Note=Localization to nuclear pores requires GTP-binding.
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