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MGP001992

UniProt Annotations

Entry Information
Gene Namev-myb avian myeloblastosis viral oncogene homolog
Protein EntryMYB_HUMAN
UniProt IDP10242
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=12; Name=1; IsoId=P10242-1; Sequence=Displayed; Name=2; IsoId=P10242-2; Sequence=VSP_003293; Name=3; IsoId=P10242-3; Sequence=VSP_003294, VSP_003295; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; IsoId=P10242-4; Sequence=VSP_003296; Note=Ref.8 (CAA35503) sequence is in conflict in position: 433:L->F. {ECO:0000305}; Name=5; IsoId=P10242-5; Sequence=VSP_003297, VSP_003298; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=6; IsoId=P10242-6; Sequence=VSP_003299; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=7; IsoId=P10242-7; Sequence=VSP_003293, VSP_003296; Name=8; IsoId=P10242-8; Sequence=VSP_046660; Name=9; IsoId=P10242-9; Sequence=VSP_046658; Name=10; IsoId=P10242-10; Sequence=VSP_046661; Name=11; IsoId=P10242-11; Sequence=VSP_046659; Name=12; IsoId=P10242-12; Sequence=VSP_053389; Note=No experimental confirmation available.;
DomainComprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C- terminal domain involved in transcriptional repression. {ECO:0000269|PubMed:2189102}.
FunctionTranscriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
InductionNegatively regulated by microRNA-155 (miR-155). {ECO:0000269|PubMed:23166356}.
InteractionQ00610:CLTC; NbExp=4; IntAct=EBI-298355, EBI-354967; O15083:ERC2; NbExp=2; IntAct=EBI-298355, EBI-2684336; P63165:SUMO1; NbExp=3; IntAct=EBI-298355, EBI-80140; P61956:SUMO2; NbExp=3; IntAct=EBI-298355, EBI-473220; O60293:ZFC3H1; NbExp=2; IntAct=EBI-298355, EBI-746701;
PtmPhosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels. {ECO:0000269|PubMed:19646965}.
PtmPhosphorylated by NLK on multiple sites, which induces proteasomal degradation. {ECO:0000250}.
PtmUbiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. {ECO:0000305}.
SimilarityContains 3 HTH myb-type DNA-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00625}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00625, ECO:0000269|PubMed:19646965}.
SubunitBinds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1. {ECO:0000250, ECO:0000269|PubMed:10747903, ECO:0000269|PubMed:19646965}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MYBID41466ch6q23.html";
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