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MGP001993

UniProt Annotations

Entry Information

Gene Name	v-myb avian myeloblastosis viral oncogene homolog-like 1
Protein Entry
UniProt ID	Q495G0
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10243-1; Sequence=Displayed; Name=2; IsoId=P10243-2; Sequence=VSP_042912; Note=No experimental confirmation available.;
Function	Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.
Similarity	Contains 3 HTH myb-type DNA-binding domains. {ECO:0000255\|PROSITE-ProRule:PRU00625}.
Subcellular Location	Nucleus.
Subunit	Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. {ECO:0000269\|PubMed:17531812}.
Tissue Specificity	Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MYBL1ID41468ch8q13.html";