MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001995

UniProt Annotations

Entry Information
Gene Namev-myb avian myeloblastosis viral oncogene homolog-like 2
Protein EntryMYBB_HUMAN
UniProt IDP10244
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10244-1; Sequence=Displayed; Name=2; IsoId=P10244-2; Sequence=VSP_053987; Note=No experimental confirmation available.;
FunctionTranscription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}.
InteractionQ6MZP7:LIN54; NbExp=4; IntAct=EBI-1389468, EBI-1389411; Q5TKA1:LIN9; NbExp=7; IntAct=EBI-1389468, EBI-1389424;
PtmPhosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity. {ECO:0000269|PubMed:10095772, ECO:0000269|PubMed:17081983, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:9840932}.
SimilarityContains 3 HTH myb-type DNA-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00625}.
Subcellular LocationNucleus.
SubunitComponent of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22. {ECO:0000269|PubMed:17531812, ECO:0000269|PubMed:17671431}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MYBL2ID41469ch20q13.html";
  logo