MGP Database

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MGP002010

UniProt Annotations

Entry Information
Gene Namemyosin, heavy chain 10, non-muscle
Protein EntryMYH10_HUMAN
UniProt IDP35580
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=P35580-1; Sequence=Displayed; Name=2; IsoId=P35580-2; Sequence=VSP_022013; Note=Contains a phosphoserine at position 214.; Name=3; IsoId=P35580-3; Sequence=VSP_022014; Name=4; IsoId=P35580-4; Sequence=VSP_046033, VSP_022014; Note=No experimental confirmation available. Contains a phosphoserine at position 214.; Name=5; IsoId=P35580-5; Sequence=VSP_054974; Note=No experimental confirmation available.;
CautionRepresents a conventional non-muscle myosin. This protein should not be confused with the unconventional myosin-10 (MYO10). {ECO:0000305}.
DomainThe rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
FunctionCellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.
PtmPhosphorylated by ABL2. {ECO:0000250}.
Sequence CautionSequence=BAE06108.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. {ECO:0000305}.
SimilarityContains 1 IQ domain. {ECO:0000255|PROSITE- ProRule:PRU00116}.
SimilarityContains 1 myosin motor domain. {ECO:0000305}.
Subcellular LocationCell projection, lamellipodium {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:22480440}. Note=Colocalizes with MCC at the leading edge of migrating cells.
SubunitMyosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B (By similarity). Interacts with LARP6. Interacts with MCC. {ECO:0000250, ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:20682791, ECO:0000269|PubMed:22480440}.
Tissue SpecificityIsoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum. {ECO:0000269|PubMed:7782316}.
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