MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002030

Record overview

MGPD IDMGP002030
Gene ID4680
SpeciesHomo sapiens (Human)
Gene Namecarcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
Gene Symbol CEACAM6
SynonymsNCA; CEAL; CD66c;
Alternate namescarcinoembryonic antigen-related cell adhesion molecule 6; Cluster of Differentiation 66c; normal cross-reacting antigen;
Chromosome19
Map Location19q13.2
SummaryThis gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
OrthologsView orthologs and multiple alignments for CEACAM6

Proteins

carcinoembryonic antigen-related cell adhesion molecule 6 preproprotein
Refseq ID:NP_002474
Protein GI:612407822
UniProt ID:P40199
mRNA ID:NM_002483
Length:344
RefSeq Status:
MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQNRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRET
IYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWVNGQSLPVSPRLQLSNGNMTL
TLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ
AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI
 
sig_peptide: 1..34
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P40199.3)
calculated_mol_wt: 3729
peptide sequence: 
MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTA

mat_peptide: 35..320
product: Carcinoembryonic antigen-related cell adhesion molecule 6
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P40199.3)
calculated_mol_wt: 31252
peptide sequence: 
KLTIESTPFNVAEGKEVLLLAHNLPQNRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEA
TGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVL
YGPDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQAHNSATGLNRTTVTMITVSG
 
  logo