MGP Database

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MGP002033

UniProt Annotations

Entry Information
Gene Nameneural cell adhesion molecule 1
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; IsoId=P13591-2; Sequence=Displayed; Name=2; Synonyms=N-CAM 140; IsoId=P13591-1; Sequence=VSP_034818; Name=3; Synonyms=N-CAM 120; IsoId=P13591-3, P13592-2; Sequence=VSP_034818, VSP_034822, VSP_034824, VSP_034825; Note=GPI-anchor amidated asparagine on Asn-741.; Name=4; IsoId=P13591-4; Sequence=VSP_034818, VSP_034824, VSP_034825; Note=GPI-anchor amidated asparagine on Asn-706.; Name=5; Synonyms=C; IsoId=P13591-5, P13592-1; Sequence=VSP_034821, VSP_034823; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=6; IsoId=P13591-6; Sequence=VSP_034819, VSP_034820;
FunctionThis protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
Sequence CautionSequence=BAD92680.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
SimilarityContains 5 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationIsoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular LocationIsoform 2: Cell membrane; Single-pass type I membrane protein.
Subcellular LocationIsoform 3: Cell membrane; Lipid-anchor, GPI- anchor.
Subcellular LocationIsoform 4: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Subcellular LocationIsoform 5: Secreted.
Subcellular LocationIsoform 6: Secreted {ECO:0000305}.
Web ResourceName=Functional Glycomics Gateway - Glycan Binding; Note=N-CAM 140; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_264";
Web ResourceName=Wikipedia; Note=NCAM entry; URL="http://en.wikipedia.org/wiki/NCAM";
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