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MGP002035

Record overview

MGPD IDMGP002035
Gene ID4688
SpeciesHomo sapiens (Human)
Gene Nameneutrophil cytosolic factor 2
Gene Symbol NCF2
SynonymsNCF-2; NOXA2; P67PHOX; P67-PHOX;
Alternate namesneutrophil cytosol factor 2; 67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; chronic granulomatous disease, autosomal 2; neutrophil NADPH oxidase factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2);
Chromosome1
Map Location1q25
SummaryThis gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
OrthologsView orthologs and multiple alignments for NCF2

Proteins

neutrophil cytosol factor 2 isoform 1
Refseq ID:NP_001121123
Protein GI:189083742
UniProt ID:P19878
mRNA ID:NM_001127651
Length:526
RefSeq Status:
MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQ
LRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVGKLFRPNERQVAQLAKKDYLG
KATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR
IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSN
ELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGECK
GKVGIFPKVFVEDCATTDLESTRREV
 
neutrophil cytosol factor 2 isoform 1
Refseq ID:NP_000424
Protein GI:67189970
UniProt ID:P19878
mRNA ID:NM_000433
Length:526
RefSeq Status:
Protein sequence is identical to GI:189083742 (mRNA isoform)
 
neutrophil cytosol factor 2 isoform 2
Refseq ID:NP_001177723
Protein GI:299829294
UniProt ID:P19878
mRNA ID:NM_001190794
Length:481
RefSeq Status:
MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQ
LRGNQLIDYKILGLQFKLFACEKQKLYEPVVIPVGKLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAH
RVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVK
LSVPMPYTLKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPKESEKA
DANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV
 
neutrophil cytosol factor 2 isoform 3
Refseq ID:NP_001177718
Protein GI:299829279
UniProt ID:P19878
mRNA ID:NM_001190789
Length:445
RefSeq Status:
MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQ
LRGNQLIDYKILGLQFKLFACEVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVM
FNGQKGLVPCNYLEPVELRIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKYTVVMKTQPGLPYSQVRDMVSK
KLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQEG
DIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV
 
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