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MGP002036

Record overview

MGPD IDMGP002036
Gene ID4689
SpeciesHomo sapiens (Human)
Gene Nameneutrophil cytosolic factor 4, 40kDa
Gene Symbol NCF4
SynonymsNCF; P40PHOX; SH3PXD4;
Alternate namesneutrophil cytosol factor 4; NCF-4; SH3 and PX domain-containing protein 4; neutrophil NADPH oxidase factor 4; p40-phox;
Chromosome22
Map Location22q13.1
SummaryThe protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for NCF4

Proteins

neutrophil cytosol factor 4 isoform 1
Refseq ID:NP_000622
Protein GI:47519798
UniProt ID:Q15080
mRNA ID:NM_000631
Length:339
RefSeq Status:
MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQE
IAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLL
SRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSD
EDVALMVRQARGLPSQKRLFPWKLHITQKDNYRVYNTMP
 
neutrophil cytosol factor 4 isoform 2
Refseq ID:NP_038202
Protein GI:163644267
UniProt ID:Q15080
mRNA ID:NM_013416
Length:348
RefSeq Status:
MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQE
IAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLL
SRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKSVAWEGGACPAFLPSLRPLPLTSPSHGSLSHSKAPSGSQMSHNAVTS
HQRPGWPGQPHSPFPHPTPHFQPDASLLQPVTPLGTSRWRKISAALPY
 
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