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MGP002054

Record overview

MGPD IDMGP002054
Gene ID4711
SpeciesHomo sapiens (Human)
Gene NameNADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
Gene Symbol NDUFB5
SynonymsSGDH; CISGDH;
Alternate namesNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; NADH-ubiquinone oxidoreductase SGDH subunit; complex I SGDH subunit; complex I-SGDH;
Chromosome3
Map Location3q26.33
SummaryThe protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
OrthologsView orthologs and multiple alignments for NDUFB5

Proteins

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 1 precursor
Refseq ID:NP_002483
Protein GI:4505363
UniProt ID:O43674
mRNA ID:NM_002492
Length:189
RefSeq Status:
MAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPVRHSGDHGKRLFVIRPSRFYDRRFLKLLRFYIALTGIPVAIFITLVNVFIGQAELAE
IPEGYVPEHWEYYKHPISRWIARNFYDSPEKIYERTMAVLQIEAEKAELRVKELEVRKLMHVRGDGPWYYYETIDKELIDHSPKATPDN
 
transit_peptide: 1..46
calculated_mol_wt: 4767
peptide sequence: 
MAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPVRH

mat_peptide: 47..135
product: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 3
calculated_mol_wt: 10258
peptide sequence: 
SGDHGKRLFVIRPSRFYDRRFLKLLRFYIALTGIPVAIFITLVNVFIGQAELAEIPEGYVPEHWEYYKGKGAGSAKIDACERRWTLVLL

transit_peptide: 1..46
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (O43674.1)
calculated_mol_wt: 4767
peptide sequence: 
MAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPVRH

mat_peptide: 47..189
product: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O43674.1)
calculated_mol_wt: 17002
peptide sequence: 
SGDHGKRLFVIRPSRFYDRRFLKLLRFYIALTGIPVAIFITLVNVFIGQAELAEIPEGYVPEHWEYYKHPISRWIARNFYDSPEKIYERTMAVLQIEAEK
AELRVKELEVRKLMHVRGDGPWYYYETIDKELIDHSPKATPDN
 
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 2
Refseq ID:NP_001186886
Protein GI:316660086
UniProt ID:O43674
mRNA ID:NM_001199957
Length:137
RefSeq Status:
MAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAGQAELAEIPEGYVPEHWEYYKHPISRWIARNFYDSPEKIYERTMAVLQIEAEKAELRVK
ELEVRKLMHVRGDGPWYYYETIDKELIDHSPKATPDN
 
transit_peptide: 1..46
calculated_mol_wt: 4767
peptide sequence: 
MAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPVRH

mat_peptide: 47..135
product: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 3
calculated_mol_wt: 10258
peptide sequence: 
SGDHGKRLFVIRPSRFYDRRFLKLLRFYIALTGIPVAIFITLVNVFIGQAELAEIPEGYVPEHWEYYKGKGAGSAKIDACERRWTLVLL
 
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 3 precursor
Refseq ID:NP_001186887
Protein GI:316660907
UniProt ID:O43674
mRNA ID:NM_001199958
Length:135
RefSeq Status:
MAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPVRHSGDHGKRLFVIRPSRFYDRRFLKLLRFYIALTGIPVAIFITLVNVFIGQAELAE
IPEGYVPEHWEYYKGKGAGSAKIDACERRWTLVLL
 
transit_peptide: 1..46
calculated_mol_wt: 4767
peptide sequence: 
MAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPVRH

mat_peptide: 47..135
product: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 3
calculated_mol_wt: 10258
peptide sequence: 
SGDHGKRLFVIRPSRFYDRRFLKLLRFYIALTGIPVAIFITLVNVFIGQAELAEIPEGYVPEHWEYYKGKGAGSAKIDACERRWTLVLL
 
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