MGP Database

MGP002069

Record overview

MGPD IDMGP002069
Gene ID4728
SpeciesHomo sapiens (Human)
Gene NameNADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
Gene Symbol NDUFS8
SynonymsTYKY; CI-23k; CI23KD;
Alternate namesNADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; NADH-ubiquinone oxidoreductase 23 kDa subunit; complex I 23kDa subunit; complex I-23kD;
Chromosome11
Map Location11q13
EC Number1.6.5.3
SummaryThis gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for NDUFS8

Proteins

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial precursor
Refseq ID:NP_002487
Protein GI:4505371
UniProt ID:O00217
mRNA ID:NM_002496
Length:210
RefSeq Status:
MRCLTTPMLLRALAQAARAGPPGGRSLHSSAVAATYKYVNMQDPEMDMKSVTDRAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHA
LRRYPSGEERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIA
ANIQADYLYR
 
transit_peptide: 1..34
calculated_mol_wt: 3433
peptide sequence: 
MRCLTTPMLLRALAQAARAGPPGGRSLHSSAVAA

mat_peptide: 35..210
product: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
calculated_mol_wt: 20290
peptide sequence: 
TYKYVNMQDPEMDMKSVTDRAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPRA
DGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR
 
  logo