MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002070

UniProt Annotations

Entry Information
Gene NameNADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
Protein EntryNDUV2_HUMAN
UniProt IDP19404
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityNADH + acceptor = NAD(+) + reduced acceptor.
Catalytic ActivityNADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
CofactorName=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000305}; Note=Binds 1 [2Fe-2S] cluster. {ECO:0000305};
FunctionCore subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
SimilarityBelongs to the complex I 24 kDa subunit family. {ECO:0000305}.
Subcellular LocationMitochondrion inner membrane.
SubunitComplex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. {ECO:0000269|PubMed:12611891}.
  logo