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MGP002077

Record overview

MGPD IDMGP002077
Gene ID4751
SpeciesHomo sapiens (Human)
Gene NameNIMA-related kinase 2
Gene Symbol NEK2
SynonymsNLK1; RP67; NEK2A; HsPK21; PPP1R111;
Alternate namesserine/threonine-protein kinase Nek2; NIMA (never in mitosis gene a)-related kinase 2; nimA-like protein kinase 1; nimA-related protein kinase 2; protein phosphatase 1, regulatory subunit 111;
Chromosome1
Map Location1q32.3
EC Number2.7.11.1
SummaryThis gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]
OrthologsView orthologs and multiple alignments for NEK2

Proteins

serine/threonine-protein kinase Nek2 isoform 1
Refseq ID:NP_002488
Protein GI:4505373
UniProt ID:P51955
mRNA ID:NM_002497
Length:445
RefSeq Status:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITK
GTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIW
SLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENS
ESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR
 
serine/threonine-protein kinase Nek2 isoform 2
Refseq ID:NP_001191112
Protein GI:323510690
UniProt ID:P51955
mRNA ID:NM_001204183
Length:384
RefSeq Status:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITK
GTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIW
SLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPGMRINLVNRSWCYK
 
serine/threonine-protein kinase Nek2 isoform 3
Refseq ID:NP_001191111
Protein GI:323510688
UniProt ID:P51955
mRNA ID:NM_001204182
Length:388
RefSeq Status:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITK
GTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIW
SLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPESHFVAQAGMQWCDHSSM
 
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