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MGP002083

UniProt Annotations

Entry Information
Gene Namenuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
Protein EntryNFAC3_HUMAN
UniProt IDQ12968
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; Synonyms=X1; IsoId=Q12968-1; Sequence=Displayed; Name=2; Synonyms=X2, C; IsoId=Q12968-2; Sequence=VSP_005600; Name=3; Synonyms=X3; IsoId=Q12968-3; Sequence=VSP_005601; Name=4; Synonyms=X4; IsoId=Q12968-4; Sequence=VSP_005602; Name=5; Synonyms=A; IsoId=Q12968-5; Sequence=VSP_005598; Name=6; Synonyms=B; IsoId=Q12968-6; Sequence=VSP_005599;
DomainRel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
FunctionActs as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. {ECO:0000269|PubMed:18815128}.
InteractionP04049:RAF1; NbExp=2; IntAct=EBI-5278441, EBI-365996;
PtmPhosphorylated by NFATC-kinase; dephosphorylated by calcineurin. {ECO:0000250}.
SimilarityContains 1 RHD (Rel-like) domain. {ECO:0000255|PROSITE-ProRule:PRU00265}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:18815128}. Nucleus {ECO:0000269|PubMed:18815128}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
SubunitMember of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers.
Tissue SpecificityIsoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.
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