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MGP002085

UniProt Annotations

Entry Information
Gene Namenuclear factor I/B
Protein EntryNFIB_HUMAN
UniProt IDO00712
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist.; Name=1; IsoId=O00712-1; Sequence=Displayed; Name=2; IsoId=O00712-3; Sequence=Not described; Name=3; Synonyms=NFI-B3; IsoId=O00712-2; Sequence=VSP_003545, VSP_003546; Name=4; IsoId=O00712-4; Sequence=VSP_044462; Note=No experimental confirmation available.; Name=5; IsoId=O00712-5; Sequence=VSP_045065; Note=No experimental confirmation available.; Name=6; IsoId=O00712-6; Sequence=VSP_054713, VSP_054714; Note=No experimental confirmation available.;
FunctionRecognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
SimilarityBelongs to the CTF/NF-I family. {ECO:0000255|PROSITE- ProRule:PRU00436}.
SimilarityContains 1 CTF/NF-I DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00436}.
Subcellular LocationNucleus.
SubunitBinds DNA as a homodimer.
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