MGP Database

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MGP002088

Ontology/Pathway Information

Entrez Gene ID4790
Gene Namenuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Gene Symbol NFKB1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0033256 TAS:BHF-UCLCI-kappaB/NF-kappaB complex
GO:0005739 IDA:HPACmitochondrion
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0003690 IEA:EnsemblFdouble-stranded DNA binding
GO:0000975 IDA:UniProtKBFregulatory region DNA binding
GO:0000980 IDA:NTNU_SBFRNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205 IDA:NTNU_SBFRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001227 IDA:MGIFRNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700 IDA:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0008134 IDA:MGIFtranscription factor binding
GO:0044212 IDA:BHF-UCLFtranscription regulatory region DNA binding
GO:0000976 IDA:UniProtKBFtranscription regulatory region sequence-specific DNA binding
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0071347 IEP:BHF-UCLPcellular response to interleukin-1
GO:0071354 IMP:BHF-UCLPcellular response to interleukin-6
GO:0071222 IMP:MGIPcellular response to lipopolysaccharide
GO:0071260 IEP:UniProtKBPcellular response to mechanical stimulus
GO:0071316 IMP:BHF-UCLPcellular response to nicotine
GO:0071375 IMP:BHF-UCLPcellular response to peptide hormone stimulus
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0006954 TAS:UniProtKBPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0031293 TAS:ReactomePmembrane protein intracellular domain proteolysis
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0043066 TAS:UniProtKBPnegative regulation of apoptotic process
GO:0010956 IDA:BHF-UCLPnegative regulation of calcidiol 1-monooxygenase activity
GO:0032269 IC:BHF-UCLPnegative regulation of cellular protein metabolic process
GO:0032375 IC:BHF-UCLPnegative regulation of cholesterol transport
GO:0050728 IEA:EnsemblPnegative regulation of inflammatory response
GO:0045083 IEA:EnsemblPnegative regulation of interleukin-12 biosynthetic process
GO:0000122 IMP:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0010957 IC:BHF-UCLPnegative regulation of vitamin D biosynthetic process
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0090263 IMP:UniProtKBPpositive regulation of canonical Wnt signaling pathway
GO:1900127 IDA:UniProtKBPpositive regulation of hyaluronan biosynthetic process
GO:0010884 IC:BHF-UCLPpositive regulation of lipid storage
GO:0010744 IC:BHF-UCLPpositive regulation of macrophage derived foam cell differentiation
GO:2000630 IMP:BHF-UCLPpositive regulation of miRNA metabolic process
GO:0051092 TAS:ReactomePpositive regulation of NF-kappaB transcription factor activity
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:NTNU_SBPpositive regulation of transcription from RNA polymerase II promoter
GO:0032481 TAS:ReactomePpositive regulation of type I interferon production
GO:0046688 IEA:EnsemblPresponse to copper ion
GO:0006979 IEA:EnsemblPresponse to oxidative stress
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0006366 TAS:UniProtKBPtranscription from RNA polymerase II promoter
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_118656Activation of NF-kappaB in B cells
REACT_75774Adaptive Immune System
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_75790Cytokine Signaling in Immune system
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_111045Developmental Biology
REACT_163773DEx/H-box helicases activate type I IFN and inflammatory cytokines production
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_12555Downstream TCR signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163994FCERI mediated NF-kB activation
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_23950Interleukin-1 processing
REACT_22442Interleukin-1 signaling
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_13696NF-kB is activated and signals survival
REACT_13776p75 NTR receptor-mediated signalling
REACT_13537p75NTR signals via NF-kB
REACT_13443Regulated proteolysis of p75NTR
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_22232Signaling by Interleukins
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_12526TCR signaling
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_27161Transcriptional regulation of white adipocyte differentiation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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