MGP Database

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MGP002089

Ontology/Pathway Information

Entrez Gene ID4791
Gene Namenuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Gene Symbol NFKB2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0033257 IDA:UniProtKBCBcl3/NF-kappaB2 complex
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0000978 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 TAS:ProtIncFsequence-specific DNA binding transcription factor activity
GO:0003713 TAS:ProtIncFtranscription coactivator activity
GO:0030198 IEA:EnsemblPextracellular matrix organization
GO:0002268 IEA:EnsemblPfollicular dendritic cell differentiation
GO:0002467 IEA:EnsemblPgerminal center formation
GO:0045087 TAS:ReactomePinnate immune response
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0038061 IEA:EnsemblPNIK/NF-kappaB signaling
GO:0051092 TAS:ReactomePpositive regulation of NF-kappaB transcription factor activity
GO:0045944 IDA:NTNU_SBPpositive regulation of transcription from RNA polymerase II promoter
GO:0032481 TAS:ReactomePpositive regulation of type I interferon production
GO:0006355 IDA:UniProtKBPregulation of transcription, DNA-templated
GO:0048511 IEA:UniProtKB-KWPrhythmic process
GO:0048536 IEA:EnsemblPspleen development
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_75790Cytokine Signaling in Immune system
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_163773DEx/H-box helicases activate type I IFN and inflammatory cytokines production
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_23950Interleukin-1 processing
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_22232Signaling by Interleukins
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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