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MGP002092

Record overview

MGPD IDMGP002092
Gene ID4794
SpeciesHomo sapiens (Human)
Gene Namenuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Gene Symbol NFKBIE
SynonymsIKBE;
Alternate namesNF-kappa-B inhibitor epsilon; I-kappa-B-epsilon; NF-kappa-BIE; ikB-E; ikB-epsilon; ikappaBepsilon;
Chromosome6
Map Location6p21.1
SummaryThe protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
OrthologsView orthologs and multiple alignments for NFKBIE

Proteins

NF-kappa-B inhibitor epsilon
Refseq ID:NP_004547
Protein GI:71274109
UniProt ID:O00221
mRNA ID:NM_004556
Length:500
RefSeq Status:
MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGAIRVRRPCWSGGAGRGGGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRR
PPRAGRPLCQADPQPGKAARRSLEPDPAQTGPRPARAAGMSEARKGPDEAEESQYDSGIESLRSLRSLPESTSAPASGPSDGSPQPCTHPPGPVKEPQEK
EDADGERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHL
AVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQE
GTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEESLVLLPFDDLKISGKLLLCTD
 
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