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MGP002099

UniProt Annotations

Entry Information
Gene Namenidogen 1
Protein EntryNID1_HUMAN
UniProt IDP14543
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14543-1; Sequence=Displayed; Name=2; IsoId=P14543-2; Sequence=VSP_017254;
FunctionSulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions.
PtmN- and O-glycosylated.
SimilarityContains 1 NIDO domain. {ECO:0000255|PROSITE- ProRule:PRU00570}.
SimilarityContains 1 nidogen G2 beta-barrel domain. {ECO:0000255|PROSITE-ProRule:PRU00348}.
SimilarityContains 1 thyroglobulin type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00500}.
SimilarityContains 4 LDL-receptor class B repeats. {ECO:0000255|PROSITE-ProRule:PRU00461}.
SimilarityContains 6 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
Subcellular LocationSecreted, extracellular space, extracellular matrix, basement membrane.
SubunitInteracts with FBLN1 and LGALS3BP (By similarity). Interacts with PLXDC1. {ECO:0000250, ECO:0000269|PubMed:16574105}.
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