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MGP002108

UniProt Annotations

Entry Information

Gene Name	nicotinamide N-methyltransferase
Protein Entry	NNMT_HUMAN
UniProt ID	P40261
Species	Human

Comments

Comment type	Description
Catalytic Activity	S-adenosyl-L-methionine + nicotinamide = S- adenosyl-L-homocysteine + 1-methylnicotinamide.
Function	Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
Similarity	Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. {ECO:0000305}.
Subcellular Location	Cytoplasm.
Subunit	Monomer. {ECO:0000269\|Ref.7}.
Tissue Specificity	Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NNMTID44506ch11q23.html";