MGP Database

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MGP002112

Ontology/Pathway Information

Entrez Gene ID4846
Gene Namenitric oxide synthase 3 (endothelial cell)
Gene Symbol NOS3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005901 IDA:BHF-UCLCcaveola
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005856 IEA:UniProtKB-SubCellCcytoskeleton
GO:0005829 TAS:ReactomeCcytosol
GO:0030666 TAS:ReactomeCendocytic vesicle membrane
GO:0000139 TAS:ReactomeCGolgi membrane
GO:0005634 ISS:BHF-UCLCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0003785 IPI:BHF-UCLFactin monomer binding
GO:0034618 IDA:BHF-UCLFarginine binding
GO:0046870 NAS:BHF-UCLFcadmium ion binding
GO:0050660 NAS:BHF-UCLFflavin adenine dinucleotide binding
GO:0010181 NAS:BHF-UCLFFMN binding
GO:0020037 IDA:BHF-UCLFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0050661 NAS:BHF-UCLFNADP binding
GO:0003958 IBA:GO_CentralFNADPH-hemoprotein reductase activity
GO:0004517 IDA:BHF-UCLFnitric-oxide synthase activity
GO:0034617 IDA:BHF-UCLFtetrahydrobiopterin binding
GO:0001525 IEA:EnsemblPangiogenesis
GO:0006527 IDA:BHF-UCLParginine catabolic process
GO:0007596 TAS:ReactomePblood coagulation
GO:0001974 ISS:BHF-UCLPblood vessel remodeling
GO:0043542 IMP:BHF-UCLPendothelial cell migration
GO:0051701 TAS:ReactomePinteraction with host
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0031663 IEA:EnsemblPlipopolysaccharide-mediated signaling pathway
GO:0030324 IEA:EnsemblPlung development
GO:0007005 ISS:BHF-UCLPmitochondrion organization
GO:0045776 IBA:GO_CentralPnegative regulation of blood pressure
GO:0051926 IEA:EnsemblPnegative regulation of calcium ion transport
GO:0008285 ISS:BHF-UCLPnegative regulation of cell proliferation
GO:1902042 ISS:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0051346 IEA:EnsemblPnegative regulation of hydrolase activity
GO:0014740 ISS:BHF-UCLPnegative regulation of muscle hyperplasia
GO:0010544 NAS:BHF-UCLPnegative regulation of platelet activation
GO:0043267 IEA:EnsemblPnegative regulation of potassium ion transport
GO:0006809 IDA:BHF-UCLPnitric oxide biosynthetic process
GO:0007263 IBA:GO_CentralPnitric oxide mediated signal transduction
GO:0046209 TAS:ReactomePnitric oxide metabolic process
GO:0001542 IEA:EnsemblPovulation from ovarian follicle
GO:0090382 TAS:ReactomePphagosome maturation
GO:0045766 ISS:BHF-UCLPpositive regulation of angiogenesis
GO:0031284 IMP:BHF-UCLPpositive regulation of guanylate cyclase activity
GO:0045909 NAS:BHF-UCLPpositive regulation of vasodilation
GO:0008217 NAS:BHF-UCLPregulation of blood pressure
GO:0050880 ISS:BHF-UCLPregulation of blood vessel size
GO:0050999 TAS:ReactomePregulation of nitric-oxide synthase activity
GO:0002028 IEA:EnsemblPregulation of sodium ion transport
GO:0003100 IMP:BHF-UCLPregulation of systemic arterial blood pressure by endothelin
GO:0003057 IEA:EnsemblPregulation of the force of heart contraction by chemical signal
GO:0034405 IEP:BHF-UCLPresponse to fluid shear stress
GO:0009408 NAS:BHF-UCLPresponse to heat
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0014806 ISS:BHF-UCLPsmooth muscle hyperplasia
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_12477eNOS activation
REACT_12389eNOS activation and regulation
REACT_604Hemostasis
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
REACT_111217Metabolism
REACT_12508Metabolism of nitric oxide
REACT_23862Nitric oxide stimulates guanylate cyclase
REACT_12510NOSIP mediated eNOS trafficking
REACT_12541NOSTRIN mediated eNOS trafficking
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_23876Platelet homeostasis
REACT_12529Signaling by VEGF
REACT_111102Signal Transduction
REACT_111176Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
REACT_264464VEGFA-VEGFR2 Pathway
REACT_263991VEGFR2 mediated vascular permeability
SMP Pathway Links
SMP IDDescription
SMP00650Doxorubicin Metabolism Pathway
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