MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002115

UniProt Annotations

Entry Information
Gene NameCCR4-NOT transcription complex, subunit 4
Protein EntryCNOT4_HUMAN
UniProt IDO95628
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=10; Name=1; IsoId=O95628-1; Sequence=Displayed; Name=2; IsoId=O95628-2; Sequence=VSP_009924; Name=3; IsoId=O95628-3; Sequence=VSP_009923; Note=No experimental confirmation available.; Name=4; IsoId=O95628-4; Sequence=VSP_009928; Note=No experimental confirmation available.; Name=5; IsoId=O95628-5; Sequence=VSP_009925, VSP_009926; Name=6; IsoId=O95628-6; Sequence=VSP_009927; Note=No experimental confirmation available.; Name=7; IsoId=O95628-7; Sequence=VSP_009929; Note=No experimental confirmation available.; Name=8; IsoId=O95628-8; Sequence=VSP_009924, VSP_009928; Note=No experimental confirmation available.; Name=9; IsoId=O95628-9; Sequence=VSP_009924, VSP_045469; Note=No experimental confirmation available. Ref.4 (BAH13270) sequence is in conflict in position: 545:V->I. {ECO:0000305}; Name=10; IsoId=O95628-10; Sequence=VSP_045469; Note=No experimental confirmation available.;
FunctionHas E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway. {ECO:0000269|PubMed:11823428, ECO:0000269|PubMed:22159038}.
PathwayProtein modification; protein ubiquitination.
PtmAutoubiquitinated. {ECO:0000269|PubMed:11823428, ECO:0000269|PubMed:15001359}.
Sequence CautionSequence=AAC72963.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAC72963.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAD00180.1; Type=Frameshift; Positions=358, 400; Evidence={ECO:0000305}; Sequence=BAC11125.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 C3H1-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00723}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
SimilarityContains 1 RRM (RNA recognition motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00176}.
Subcellular LocationCytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
SubunitInteracts with CNOT1 via its C-terminus but does not stably associate with the CCR4-NOT complex. Binds E2 ubiquitin ligases via its RING domain. Interacts (via RING domain) with UBE2D2. {ECO:0000269|PubMed:11087754, ECO:0000269|PubMed:11823428, ECO:0000269|PubMed:15001359}.
  logo