MGP Database

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MGP002116

Ontology/Pathway Information

Entrez Gene ID4851
Gene Namenotch 1
Gene Symbol NOTCH1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0001669 IEA:EnsemblCacrosomal vesicle
GO:0009986 IEA:EnsemblCcell surface
GO:0005829 TAS:ReactomeCcytosol
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0005576 TAS:ReactomeCextracellular region
GO:0000139 TAS:ReactomeCGolgi membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0002193 IDA:UniProtKBCMAML1-RBP-Jkappa- ICN1 complex
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 ISS:UniProtKBCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0043235 IDA:MGICreceptor complex
GO:0005509 IEA:InterProFcalcium ion binding
GO:0031490 IEA:EnsemblFchromatin DNA binding
GO:0001047 ISS:UniProtKBFcore promoter binding
GO:0019899 ISS:UniProtKBFenzyme binding
GO:0004857 ISS:UniProtKBFenzyme inhibitor activity
GO:0004872 IEA:InterProFreceptor activity
GO:0001190 ISS:BHF-UCLFRNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0043565 IEA:EnsemblFsequence-specific DNA binding
GO:0003700 IEA:EnsemblFsequence-specific DNA binding transcription factor activity
GO:0003180 IMP:BHF-UCLPaortic valve morphogenesis
GO:1902263 IEA:EnsemblPapoptotic process involved in embryonic digit morphogenesis
GO:0060842 ISS:BHF-UCLParterial endothelial cell differentiation
GO:0048708 IEA:EnsemblPastrocyte differentiation
GO:0003162 IEA:EnsemblPatrioventricular node development
GO:0003181 ISS:BHF-UCLPatrioventricular valve morphogenesis
GO:0009912 IEA:EnsemblPauditory receptor cell fate commitment
GO:0007409 IEA:EnsemblPaxonogenesis
GO:0048754 IEA:EnsemblPbranching morphogenesis of an epithelial tube
GO:0003209 ISS:BHF-UCLPcardiac atrium morphogenesis
GO:0003207 ISS:BHF-UCLPcardiac chamber formation
GO:0060317 ISS:BHF-UCLPcardiac epithelial to mesenchymal transition
GO:0003214 ISS:BHF-UCLPcardiac left ventricle morphogenesis
GO:0060038 IEA:EnsemblPcardiac muscle cell proliferation
GO:0055008 ISS:BHF-UCLPcardiac muscle tissue morphogenesis
GO:0003213 ISS:BHF-UCLPcardiac right atrium morphogenesis
GO:0003219 IEA:EnsemblPcardiac right ventricle formation
GO:0060411 ISS:BHF-UCLPcardiac septum morphogenesis
GO:0060948 ISS:BHF-UCLPcardiac vascular smooth muscle cell development
GO:0003208 ISS:BHF-UCLPcardiac ventricle morphogenesis
GO:0021515 IEA:EnsemblPcell differentiation in spinal cord
GO:0001708 IEA:EnsemblPcell fate specification
GO:0003273 ISS:BHF-UCLPcell migration involved in endocardial cushion formation
GO:0071372 IDA:BHF-UCLPcellular response to follicle-stimulating hormone stimulus
GO:0035924 IDA:UniProtKBPcellular response to vascular endothelial growth factor stimulus
GO:0060271 ISS:UniProtKBPcilium morphogenesis
GO:0072044 IEA:EnsemblPcollecting duct development
GO:0007386 IEA:EnsemblPcompartment pattern specification
GO:0060982 ISS:BHF-UCLPcoronary artery morphogenesis
GO:0003169 ISS:BHF-UCLPcoronary vein morphogenesis
GO:0007368 ISS:BHF-UCLPdetermination of left/right symmetry
GO:0072017 IEA:EnsemblPdistal tubule development
GO:0035116 IEA:EnsemblPembryonic hindlimb morphogenesis
GO:0060956 ISS:BHF-UCLPendocardial cell differentiation
GO:0003203 ISS:BHF-UCLPendocardial cushion morphogenesis
GO:0003157 ISS:BHF-UCLPendocardium development
GO:0003160 ISS:BHF-UCLPendocardium morphogenesis
GO:0007492 IEA:EnsemblPendoderm development
GO:0001837 ISS:BHF-UCLPepithelial to mesenchymal transition
GO:0003198 ISS:BHF-UCLPepithelial to mesenchymal transition involved in endocardial cushion formation
GO:0030900 IEA:EnsemblPforebrain development
GO:0007440 IEA:EnsemblPforegut morphogenesis
GO:0010467 TAS:ReactomePgene expression
GO:0072144 IEA:EnsemblPglomerular mesangial cell development
GO:0003241 ISS:BHF-UCLPgrowth involved in heart morphogenesis
GO:0031069 IEA:EnsemblPhair follicle morphogenesis
GO:0007507 IMP:DFLATPheart development
GO:0001947 ISS:BHF-UCLPheart looping
GO:0061384 ISS:BHF-UCLPheart trabecula morphogenesis
GO:0006959 IEA:EnsemblPhumoral immune response
GO:0006955 NAS:UniProtKBPimmune response
GO:0002437 IEA:EnsemblPinflammatory response to antigenic stimulus
GO:0072602 IEA:EnsemblPinterleukin-4 secretion
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0030216 IEA:EnsemblPkeratinocyte differentiation
GO:0070986 IEA:EnsemblPleft/right axis specification
GO:0001889 IEA:EnsemblPliver development
GO:0030324 IEA:EnsemblPlung development
GO:0014031 ISS:BHF-UCLPmesenchymal cell development
GO:0003192 IMP:BHF-UCLPmitral valve formation
GO:2000811 IMP:BHF-UCLPnegative regulation of anoikis
GO:0030514 ISS:BHF-UCLPnegative regulation of BMP signaling pathway
GO:0045955 IEA:EnsemblPnegative regulation of calcium ion-dependent exocytosis
GO:0090090 IEA:EnsemblPnegative regulation of canonical Wnt signaling pathway
GO:0043086 ISS:UniProtKBPnegative regulation of catalytic activity
GO:0090051 IDA:UniProtKBPnegative regulation of cell migration involved in sprouting angiogenesis
GO:0008285 IDA:UniProtKBPnegative regulation of cell proliferation
GO:0010812 IDA:BHF-UCLPnegative regulation of cell-substrate adhesion
GO:2001027 IDA:UniProtKBPnegative regulation of endothelial cell chemotaxis
GO:0060253 ISS:UniProtKBPnegative regulation of glial cell proliferation
GO:0045662 IMP:UniProtKBPnegative regulation of myoblast differentiation
GO:0010832 ISS:UniProtKBPnegative regulation of myotube differentiation
GO:0050768 ISS:UniProtKBPnegative regulation of neurogenesis
GO:0048715 ISS:UniProtKBPnegative regulation of oligodendrocyte differentiation
GO:0030279 ISS:BHF-UCLPnegative regulation of ossification
GO:0045668 ISS:BHF-UCLPnegative regulation of osteoblast differentiation
GO:0046533 IEA:EnsemblPnegative regulation of photoreceptor cell differentiation
GO:2000974 ISS:UniProtKBPnegative regulation of pro-B cell differentiation
GO:2000737 IMP:UniProtKBPnegative regulation of stem cell differentiation
GO:0045892 ISS:BHF-UCLPnegative regulation of transcription, DNA-templated
GO:0000122 ISS:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0021915 IEA:EnsemblPneural tube development
GO:0097150 IEP:UniProtKBPneuronal stem cell maintenance
GO:0007220 TAS:ReactomePNotch receptor processing
GO:0061314 IMP:BHF-UCLPNotch signaling involved in heart development
GO:0007219 IMP:UniProtKBPNotch signaling pathway
GO:0003270 IEA:EnsemblPNotch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0048709 IEA:EnsemblPoligodendrocyte differentiation
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0003344 ISS:BHF-UCLPpericardium morphogenesis
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0048711 ISS:UniProtKBPpositive regulation of astrocyte differentiation
GO:0030513 ISS:UniProtKBPpositive regulation of BMP signaling pathway
GO:0060045 ISS:BHF-UCLPpositive regulation of cardiac muscle cell proliferation
GO:0030335 ISS:BHF-UCLPpositive regulation of cell migration
GO:0008284 IDA:UniProtKBPpositive regulation of cell proliferation
GO:0045603 IEA:EnsemblPpositive regulation of endothelial cell differentiation
GO:0050679 IEA:EnsemblPpositive regulation of epithelial cell proliferation
GO:0010718 IMP:BHF-UCLPpositive regulation of epithelial to mesenchymal transition
GO:0046427 ISS:UniProtKBPpositive regulation of JAK-STAT cascade
GO:0045618 IEA:EnsemblPpositive regulation of keratinocyte differentiation
GO:0002052 IEA:EnsemblPpositive regulation of neuroblast proliferation
GO:0045893 ISS:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0061419 ISS:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0007221 ISS:BHF-UCLPpositive regulation of transcription of Notch receptor target
GO:0060740 IEA:EnsemblPprostate gland epithelium morphogenesis
GO:0003184 IMP:BHF-UCLPpulmonary valve morphogenesis
GO:0060768 IEA:EnsemblPregulation of epithelial cell proliferation involved in prostate gland development
GO:1901201 ISS:BHF-UCLPregulation of extracellular matrix assembly
GO:0014807 IEA:EnsemblPregulation of somitogenesis
GO:0006355 TAS:UniProtKBPregulation of transcription, DNA-templated
GO:0003256 ISS:BHF-UCLPregulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0031960 IEA:EnsemblPresponse to corticosteroid
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
GO:0032495 IEA:EnsemblPresponse to muramyl dipeptide
GO:0060528 IEA:EnsemblPsecretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0035914 IEA:EnsemblPskeletal muscle cell differentiation
GO:0048103 IEA:EnsemblPsomatic stem cell division
GO:0007283 IEA:EnsemblPspermatogenesis
GO:0002040 IEA:EnsemblPsprouting angiogenesis
GO:0042246 IEA:EnsemblPtissue regeneration
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0035148 IMP:UniProtKBPtube formation
GO:0060979 ISS:BHF-UCLPvasculogenesis involved in coronary vascular morphogenesis
GO:0060843 ISS:BHF-UCLPvenous endothelial cell differentiation
GO:0060412 IMP:BHF-UCLPventricular septum morphogenesis
GO:0003222 ISS:BHF-UCLPventricular trabecula myocardium morphogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118614Activated NOTCH1 Transmits Signal to the Nucleus
REACT_160089Constitutive Signaling by NOTCH1 HD Domain Mutants
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_160106Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_111045Developmental Biology
REACT_116125Disease
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_160305Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_14835Notch-HLH transcription pathway
REACT_118744Pre-NOTCH Expression and Processing
REACT_118798Pre-NOTCH Processing in Golgi
REACT_118722Pre-NOTCH Processing in the Endoplasmic Reticulum
REACT_118568Pre-NOTCH Transcription and Translation
REACT_13698Regulation of beta-cell development
REACT_13673Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_111102Signal Transduction
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