MGP Database

MGP002118

Ontology/Pathway Information

Entrez Gene ID	4853
Gene Name	notch 2
Gene Symbol	NOTCH2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0005929	IEA:Ensembl	C	cilium
GO:0005789	TAS:Reactome	C	endoplasmic reticulum membrane
GO:0005576	TAS:Reactome	C	extracellular region
GO:0000139	TAS:Reactome	C	Golgi membrane
GO:0005887	IDA:UniProtKB	C	integral component of plasma membrane
GO:0016020	IDA:UniProtKB	C	membrane
GO:0005654	TAS:Reactome	C	nucleoplasm
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0043235	IDA:MGI	C	receptor complex
GO:0005509	IEA:InterPro	F	calcium ion binding
GO:0038049	TAS:UniProtKB	F	ligand-activated RNA polymerase II transcription factor binding transcription factor activity
GO:0004872	NAS:UniProtKB	F	receptor activity
GO:0006915	TAS:UniProtKB	P	apoptotic process
GO:0060413	IMP:BHF-UCL	P	atrial septum morphogenesis
GO:0046849	IMP:UniProtKB	P	bone remodeling
GO:0007050	IDA:UniProtKB	P	cell cycle arrest
GO:0001709	TAS:UniProtKB	P	cell fate determination
GO:0016049	IDA:UniProtKB	P	cell growth
GO:0061073	IEA:Ensembl	P	ciliary body morphogenesis
GO:0007368	IEA:Ensembl	P	determination of left/right symmetry
GO:0030326	IEA:Ensembl	P	embryonic limb morphogenesis
GO:0010467	TAS:Reactome	P	gene expression
GO:0030097	TAS:UniProtKB	P	hemopoiesis
GO:0006959	IEA:Ensembl	P	humoral immune response
GO:0002437	IEA:Ensembl	P	inflammatory response to antigenic stimulus
GO:0072602	IEA:Ensembl	P	interleukin-4 secretion
GO:0030522	TAS:GOC	P	intracellular receptor signaling pathway
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0002011	IEA:Ensembl	P	morphogenesis of an epithelial sheet
GO:0007275	NAS:UniProtKB	P	multicellular organismal development
GO:0043066	TAS:UniProtKB	P	negative regulation of apoptotic process
GO:0008285	IDA:UniProtKB	P	negative regulation of cell proliferation
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0007399	NAS:UniProtKB	P	nervous system development
GO:0007220	TAS:Reactome	P	Notch receptor processing
GO:0061314	IC:BHF-UCL	P	Notch signaling involved in heart development
GO:0007219	TAS:Reactome	P	Notch signaling pathway
GO:0009887	IEP:UniProtKB	P	organ morphogenesis
GO:0060674	IEA:Ensembl	P	placenta blood vessel development
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0030513	IEA:Ensembl	P	positive regulation of BMP signaling pathway
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0046579	IDA:UniProtKB	P	positive regulation of Ras protein signal transduction
GO:0003184	IMP:BHF-UCL	P	pulmonary valve morphogenesis
GO:0006355	TAS:UniProtKB	P	regulation of transcription, DNA-templated
GO:0019827	TAS:UniProtKB	P	stem cell maintenance
GO:0006367	TAS:Reactome	P	transcription initiation from RNA polymerase II promoter

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_71	Gene Expression
REACT_12627	Generic Transcription Pathway
REACT_160205	NOTCH2 Activation and Transmission of Signal to the Nucleus
REACT_163910	NOTCH2 intracellular domain regulates transcription
REACT_14835	Notch-HLH transcription pathway
REACT_118744	Pre-NOTCH Expression and Processing
REACT_118798	Pre-NOTCH Processing in Golgi
REACT_118722	Pre-NOTCH Processing in the Endoplasmic Reticulum
REACT_118568	Pre-NOTCH Transcription and Translation
REACT_299	Signaling by NOTCH
REACT_118721	Signaling by NOTCH2
REACT_111102	Signal Transduction