MGP Database

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MGP002121

Ontology/Pathway Information

Entrez Gene ID4860
Gene Namepurine nucleoside phosphorylase
Gene Symbol PNP
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005856 IEA:UniProtKB-SubCellCcytoskeleton
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005622 IDA:UniProtKBCintracellular
GO:0008144 IDA:UniProtKBFdrug binding
GO:0001882 IDA:UniProtKBFnucleoside binding
GO:0042301 IDA:UniProtKBFphosphate ion binding
GO:0002060 IDA:UniProtKBFpurine nucleobase binding
GO:0004731 IDA:UniProtKBFpurine-nucleoside phosphorylase activity
GO:0006955 IMP:UniProtKBPimmune response
GO:0006148 IDA:MGIPinosine catabolic process
GO:0070970 IMP:UniProtKBPinterleukin-2 secretion
GO:0034356 IGI:UniProtKBPNAD biosynthesis via nicotinamide riboside salvage pathway
GO:0006738 IDA:UniProtKBPnicotinamide riboside catabolic process
GO:0006139 IDA:UniProtKBPnucleobase-containing compound metabolic process
GO:0055086 TAS:ReactomePnucleobase-containing small molecule metabolic process
GO:0046638 IDA:MGIPpositive regulation of alpha-beta T cell differentiation
GO:0042102 IDA:MGIPpositive regulation of T cell proliferation
GO:0043101 TAS:ReactomePpurine-containing compound salvage
GO:0006144 TAS:ReactomePpurine nucleobase metabolic process
GO:0006195 TAS:ReactomePpurine nucleotide catabolic process
GO:0042493 IDA:UniProtKBPresponse to drug
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0034418 IDA:MGIPurate biosynthetic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111217Metabolism
REACT_1698Metabolism of nucleotides
REACT_2086Purine catabolism
REACT_522Purine metabolism
REACT_1923Purine salvage
SMP Pathway Links
SMP IDDescription
SMP00535Adenine phosphoribosyltransferase deficiency (APRT)
SMP00144Adenosine Deaminase Deficiency
SMP00167Adenylosuccinate Lyase Deficiency
SMP00168AICA-Ribosiduria
SMP00427Azathioprine Action Pathway
SMP00365Gout or Kelley-Seegmiller Syndrome
SMP00364Lesch-Nyhan Syndrome (LNS)
SMP00428Mercaptopurine Action Pathway
SMP00536Mitochondrial DNA depletion syndrome
SMP00203Molybdenum Cofactor Deficiency
SMP00537Myoadenylate deaminase deficiency
SMP00048Nicotinate and Nicotinamide Metabolism
SMP00050Purine Metabolism
SMP00210Purine Nucleoside Phosphorylase Deficiency
SMP00430Thioguanine Action Pathway
SMP00220Xanthine Dehydrogenase Deficiency (Xanthinuria)
SMP00512Xanthinuria type I
SMP00513Xanthinuria type II
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